Reversing direct factor Xa or thrombin inhibitors: Factor V addition to prothrombin complex concentrate is beneficial in vitro.
Herm Jan M BrinkmanFrauke SwieringaMarleen ZuurveldAlicia VeningaSanne L N BrounsJohan W M HeemskerkJoost C M MeijersPublished in: Research and practice in thrombosis and haemostasis (2022)
Our in vitro study demonstrates a beneficial effect of the combined use of PCC and FVC in DOAC reversal.