Dual Blockade of PD-1 and LAG3 Immune Checkpoints Increases Dendritic Cell Vaccine Mediated T Cell Responses in Breast Cancer Model.
Asal BarshidiVahid KarpishehFatemeh Karimian NoukabadiFariba Karoon KianiMohammad MohammadiNegin AfsharimaneshFarbod EbrahimiSeyed Hossein KiaieJamshid Gholizadeh NavashenaqMohammad Hojjat-FarsangiNaime Majidi ZolbaninAta MahmoodpoorHadi HassanniaSanam NamiPooya JalaliReza JafariFarhad Jadidi-NiaraghPublished in: Pharmaceutical research (2022)
These findings strongly suggest that TMC-DS-L NPs loaded with siRNA could act as a novel tool in inhibiting the expression of immune checkpoints in the tumor microenvironment. Also, combination therapy based on inhibition of PD-1 and LAG3 in combination with DC vaccine is an effective method in treating cancer that needs to be further studied.