Role of the OATP Transporter Family and a Benzbromarone-SensitiveEfflux Transporter in the Hepatocellular Disposition of Vincristine.
Johan NicolaiLouise ThevelinQi BingBruno StiegerHugues ChanteuxPatrick AugustijnsPieter AnnaertPublished in: Pharmaceutical research (2017)
Our findings show the involvement of OATP transporters in the disposition of vincristine in rat and human hepatocytes. However, in both species, hepatic uptake is overshadowed by a benzbromarone-sensitive efflux mechanism, possibly MRP3.