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Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study.

Jennifer A LigibelDeborah DillonAnita Giobbie-HurderAnne McTiernanElizabeth FrankMacIntosh Grant CornwellMatthew PunNancy CampbellRyan J O DowlingMartin C ChangSara TolaneyAnees B ChagparRachel L YungRachel A FreedmanLaura S DominiciMehra GolshanEsther RheiKrishan TanejaYing HuangMyles BrownEric P WinerRinath JeselsohnMelinda L Irwin
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
A window-of-opportunity exercise intervention did not impact proliferation but led to alterations in gene expression in breast tumors, suggesting that exercise may have a direct effect on breast cancer.See related commentary by Koelwyn and Jones, p. 5179.
Keyphrases
  • gene expression
  • high intensity
  • randomized controlled trial
  • physical activity
  • dna methylation
  • signaling pathway
  • resistance training
  • healthcare
  • mental health
  • health promotion
  • breast cancer risk