BRCA mutations lead to XIAP overexpression and sensitise ovarian cancer to inhibitor of apoptosis (IAP) family inhibitors.

Mattia CremonaCassandra J VandenbergAngela M FarrellyStephen F MaddenClare MorganRoshni KalachandJessica N McAlpineSinead ToomeyDavid G HuntsmanLiam GroganOscar BreathnachPatrick MorrisMark S CareyClare L ScottBryan T Hennessy

Published in: British journal of cancer (2022)

A clinical trial may be justified to further investigate the utility of IAP inhibitors.

Keyphrases

clinical trial
oxidative stress
endoplasmic reticulum stress
cell proliferation
cell cycle arrest
transcription factor
open label
phase ii
study protocol
randomized controlled trial
double blind
phase iii
pi k akt