Clinicopathological findings, prognosis, and Epstein-Barr virus infection in rheumatoid arthritis patients with other iatrogenic immunodeficiency-associated T- and NK-cell lymphoproliferative disorders.
Shoichi KimuraYumi OshiroHiromi IwasakiMasanori KadowakiMasao OgataTsutomu DaaToshifumi SakataShigeto KawauchiZiyao WangYasushi TakamatsuMorishige TakeshitaPublished in: BMC cancer (2022)
OIIA TNK-LPDs occurred in early phase of RA, compared with OIIA B-LPDs, and occasionally showed a lethal progressive clinical course. Detection of OIIA TNK-LPD patients with poor prognostic factors is necessary. EBV infection in immunosuppressed patients due to persistent RA, MTX, and biologic drugs may play a role in forming the tumour microenvironment and lymphomagenesis of TNK-LPDs.
Keyphrases
- epstein barr virus
- prognostic factors
- rheumatoid arthritis patients
- rheumatoid arthritis
- disease activity
- diffuse large b cell lymphoma
- nk cells
- end stage renal disease
- ejection fraction
- newly diagnosed
- multiple sclerosis
- stem cells
- ankylosing spondylitis
- peritoneal dialysis
- quantum dots
- patient reported outcomes
- real time pcr
- loop mediated isothermal amplification