Please eat (only part) of me: synaptic phosphatidylserine cues microglia to feast: Two new studies identify how a common apoptotic cell flag is used to sculpt neural circuits.
Graham PeetF Chris BennettMariko L BennettPublished in: The EMBO journal (2020)
Microglia, the brain's tissue-resident macrophages, contribute to the developmental elimination of extranumerary synapses and to pathologic synapse loss in mouse models of neurodegeneration. Two papers published in The EMBO Journal reveal that phosphatidylserine (PS) is a neuronal cue for microglial synapse elimination.
Keyphrases
- inflammatory response
- neuropathic pain
- single cell
- mouse model
- cell death
- lipopolysaccharide induced
- cerebral ischemia
- lps induced
- spinal cord
- cell therapy
- spinal cord injury
- genome wide
- patient safety
- resting state
- locally advanced
- case control
- radiation therapy
- systematic review
- anti inflammatory
- randomized controlled trial
- stem cells
- dna methylation
- gene expression
- brain injury
- bone marrow
- subarachnoid hemorrhage
- rectal cancer