Evaluation of optimal biopsy location for assessment of histological activity, transcriptomic and immunohistochemical analyses in patients with active Crohn's disease.
Gregor NovakToer W StevensTanja Van ViegenPeter BossuytBorut ŠtabucJenny JeyarajahGuangyong ZouIngrid C GaemersTrevor D McKeeFred FuLisa M ShackeltonReena KhannaGijs R van den BrinkWilliam J SandbornBrian G FeaganRish K PaiVipul JairathNiels Vande CasteeleGeert D'HaensPublished in: Alimentary pharmacology & therapeutics (2019)
Biopsies from the ulcer edge in patients with Crohn's disease yielded the greatest histological disease activity and mRNA levels and had similar readouts in the colon and ileum. Research is needed to confirm this conclusion for other measures.