Enrichment of CCR6+ CD8+ T cells and CCL20 in the lungs of mechanically ventilated patients with COVID-19.
Anno SarisTom D Y ReijndersMartine ReijmJolien C HollanderKim de BuckAlex R SchuurmanJanWillem DuitmanLeo HeunksJurjan AmanHarm Jan BogaardEsther J NossentTom van der PollEsther J Nossentnull nullPublished in: European journal of immunology (2021)
Despite high levels of CXCR3 ligands in mechanically ventilated COVID-19 patients, BALF CD8 T cells were not enriched in CXCR3+ cells but rather CCR6+ , likely due to high CCL20 levels in BALF, and had very high PD-1 expression. In mechanically ventilated, but not ward, patients Th-1 immunity is impaired. .
Keyphrases
- intensive care unit
- acute respiratory distress syndrome
- end stage renal disease
- induced apoptosis
- newly diagnosed
- ejection fraction
- chronic kidney disease
- dendritic cells
- poor prognosis
- sars cov
- regulatory t cells
- prognostic factors
- liver fibrosis
- liver injury
- cell cycle arrest
- oxidative stress
- extracorporeal membrane oxygenation
- drug induced
- binding protein
- cell proliferation