Clinical characteristics, time course, treatment and outcomes of patients with immune checkpoint inhibitor-associated myocarditis.
Igor PuzanovPoornima SubramanianYan V YatsynovichDavid M JacobsMaya R ChilbertUmesh C SharmaFumito ItoSteven G FeuersteinFilip StefanovicBenjamin SwitzerMark D HicarAnne B CurtisEdward J SpangenthalGrace K DyMarc S ErnstoffPankit VachhaniBrian J PageNikhil AgrawalArjun KhungerAnkita KapoorAlexander HattoumJerome J SchentagPublished in: Journal for immunotherapy of cancer (2022)
Routine troponin surveillance may be helpful in predicting mortality in ICI-treated patients with cancer in the early phase of ICI therapy initiation. Early detection of troponin elevation is associated with earlier intervention and improved outcomes in ICI-associated myocarditis. The recommended assessment and diagnostic studies guiding treatment decisions are presented.