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Effectiveness, safety, initial optimal dose, and optimal maintenance dose range of basal insulin regimens for type 2 diabetes: A systematic review with meta-analysis.

Yingying LuoJun XiaZhan ZhaoYaping ChangYong Mong BeeKhue Thy NguyenSoo LimDaisuke YabeMargaret McGillAlice Pik-Shan KongSiew Pheng ChanMarisa DeodatChaicharn DeerochanawongKetut SuastikaChenchen XuLiming ChenWei ChenXiaoying LiWeigang ZhaoXiaomei YaoLi-Nong Ji
Published in: Journal of diabetes (2023)
The five basal insulins are effective for the target population. Glargine U-300, degludec U-100, glargine U-100, and detemir lead to fewer hypoglycemic events than NPH without compromising glycemic control.
Keyphrases
  • glycemic control
  • type diabetes
  • blood glucose
  • insulin resistance
  • weight loss
  • randomized controlled trial
  • systematic review
  • cardiovascular disease
  • skeletal muscle
  • metabolic syndrome