Human blood metabolites and lacunar stroke: A Mendelian randomization study.
Meng-Nan GuoXiao-Yan HaoJie TianYun-Chao WangJia-Di LiYu FanJing-Jing ShiDong-Rui MaShuang-Jie LiChun-Yan ZuoYuan-Yuan LiangMeng-Jie LiSi ShenFen LiuDa-Bao YaoYu-Ming XuChang-He ShiPublished in: International journal of stroke : official journal of the International Stroke Society (2022)
We identified eight risk and seven protective human serum metabolites associated with lacunar stroke. Isobutyrylcarnitine was positively associated with an increased risk of lacunar stroke. In addition, 3-methyl-2-oxovalerate and aspartate may be involved in the disease pathogenesis through metabolic pathways.