Microbial manipulation as therapy for primary sclerosing cholangitis.
Damjana BogaticRobert V BryantKate D LynchSamuel Paul CostelloPublished in: Alimentary pharmacology & therapeutics (2022)
The gut-liver axis is increasingly considered a potential target for the treatment of PSC. However, no therapies have been demonstrated to improve transplant-free survival. Innovative and well-designed clinical trials of microbiome-targeted therapies with long-term follow-up are required for this orphan disease.