Fetal hemodynamic response to aortic valvuloplasty and postnatal outcome: a European multicenter study.
A KovacevicA ÖhmanG TulzerU HerbergJ DangelJulene S CarvalhoV FesslovaH JicinskaT SarkolaC PedrozaI E AverissM MellanderHelena M Gardinernull nullPublished in: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2018)
We report improvements in fetal hemodynamics and preservation of left heart growth following successful FV compared with NH. While the proportion of those achieving a BV circulation outcome was similar in both cohorts, FV survivors showed improved survival independent of final circulation to 10 years' follow-up. However, FV is associated with a 10% procedure-related loss and increased prematurity compared with the NH cohort, and therefore the risk-to-benefit ratio remains uncertain. We recommend a carefully designed trial incorporating appropriate and integrated fetal and postnatal management strategies to account for center-specific practices, so that the benefits achieved by fetal therapy vs surgical strategy can be demonstrated clearly. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
Keyphrases
- preterm infants
- primary care
- healthcare
- room temperature
- clinical trial
- heart failure
- aortic valve
- low birth weight
- study protocol
- randomized controlled trial
- atrial fibrillation
- stem cells
- pulmonary hypertension
- bone marrow
- pulmonary artery
- transcatheter aortic valve implantation
- pulmonary arterial hypertension
- free survival
- drug induced
- smoking cessation