Gene expression signature of atypical breast hyperplasia and regulation by SFRP1.
Kelly J GregoryAmy L RobertsErin M ConlonJacob A MayfieldMary J HagenGiovanna M CrisiBrooke A BentleyJeffrey J KaneGrace Makari-JudsonHolly S MasonJun YuLihua Julie ZhuKarl SiminJacob P S JohnsonAshraf KhanBen R SchneiderSallie S SchneiderD Joseph JerryPublished in: Breast cancer research : BCR (2019)
The alterations in gene expression were observed in both ductal and lobular AH suggesting shared underlying mechanisms predisposing to AH. Loss of SFRP1 expression is a significant regulator of AH transcriptional profiles driving previously unidentified changes affecting responses to estrogen and possibly other pathways. The gene signature and pathways provide insights into alterations contributing to AH breast lesions.