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Metformin effectively restores the HPA axis function in diet-induced obese rats.

Andrew C ShinPriya BalasubramanianPavan SuryadevaraJustin ZyskowskiThomas H HerdtSheba M J MohanKumarPuliyur S MohanKumar
Published in: International journal of obesity (2005) (2020)
These findings suggest that oral metformin can successfully correct HPA axis dysfunction that is associated with lowered circulating free fatty acids in DIO rats, thereby uncovering a novel effect of metformin in the treatment of obesity.
Keyphrases
  • metabolic syndrome
  • weight loss
  • fatty acid
  • type diabetes
  • insulin resistance
  • adipose tissue
  • oxidative stress
  • weight gain
  • high fat diet induced
  • combination therapy
  • obese patients
  • skeletal muscle
  • replacement therapy