Comparative Effectiveness and Safety of Direct Oral Anticoagulants Compared with Warfarin in Patients with Low Bodyweight who have Atrial Fibrillation: A Systematic Review and Meta-analysis.
Mohamed Nabil ElshafeiAhmed El-BardissyMuhammad SalemMohamed S AbdelmoneimAhmed KhalilSherine ElhadadMohammed DanjumaPublished in: American journal of cardiovascular drugs : drugs, devices, and other interventions (2024)
) was associated with a significant reduction in risks of stroke and major bleeding compared with patient cohorts stabilized on warfarin-based therapy. There was uncertainty regarding the composite outcome and mortality point estimate between these two anticoagulation strategies. This finding helps to resolve the uncertainty associated with the use of DOACs in this cohort. Additionally, it suggests the need for confirmatory non-inferiority randomized controlled trials evaluating DOACs versus warfarin in this cohort of patients.
Keyphrases
- direct oral anticoagulants
- atrial fibrillation
- venous thromboembolism
- oral anticoagulants
- catheter ablation
- left atrial
- left atrial appendage
- end stage renal disease
- randomized controlled trial
- heart failure
- percutaneous coronary intervention
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- stem cells
- cardiovascular events
- case report
- cardiovascular disease
- systematic review
- coronary artery disease
- cell therapy
- climate change
- mesenchymal stem cells
- mitral valve
- acute coronary syndrome
- left ventricular
- smoking cessation