Heat Shock Factors in Protein Quality Control and Spermatogenesis.
Vinod K NelsonSourav PaulShubhadeep RoychoudhuryIfeoluwa Temitayo OyeyemiSubhash C MandalN KumarValuathan RavichandiranMahadeb PalPublished in: Advances in experimental medicine and biology (2022)
Proper regulation of cellular protein quality control is crucial for cellular health. It appears that the protein quality control machinery is subjected to distinct regulation in different cellular contexts such as in somatic cells and in germ cells. Heat shock factors (HSFs) play critical role in the control of quality of cellular proteins through controlling expression of many genes encoding different proteins including those for inducible protein chaperones. Mammalian cells exert distinct mechanism of cellular functions through maintenance of tissue-specific HSFs. Here, we have discussed different HSFs and their functions including those during spermatogenesis. We have also discussed the different heat shock proteins induced by the HSFs and their activities in those contexts. We have also identified several small molecule activators and inhibitors of HSFs from different sources reported so far.
Keyphrases
- heat shock
- quality control
- heat stress
- small molecule
- heat shock protein
- protein protein
- induced apoptosis
- oxidative stress
- binding protein
- healthcare
- amino acid
- cell cycle arrest
- poor prognosis
- public health
- mental health
- long non coding rna
- drinking water
- gene expression
- health information
- climate change
- cell proliferation