p21-activated kinase 4 inhibition protects against liver ischemia/reperfusion injury: Role of nuclear factor erythroid 2-related factor 2 phosphorylation.

Yuancheng MaoChang Yeob HanLihua HaoYounho LeeJung Beom SonHwangeun ChoiMi Rin LeeJae Do YangSuk Kyun HongKyung-Suk SuhHee Chul YuNam Doo KimEun Ju Bae Byung-Hyun Park

Published in: Hepatology (Baltimore, Md.) (2022)

PAK4 phosphorylates Nrf2 and suppresses its transcriptional activity. Genetic or pharmacological suppression of PAK4 alleviates HIR injury. Thus, PAK4 inhibition may represent a promising intervention against I/R-induced liver injury.

Keyphrases

nuclear factor
ischemia reperfusion injury
toll like receptor
oxidative stress
randomized controlled trial
protein kinase
signaling pathway
genome wide
mouse model
inflammatory response