Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1.
Jonathan F ThomasMarco Igor Valencia-SánchezSimone TamburriSusan L GloorSamantha RustichelliVictoria Godínez-LópezPablo De IoannesRachel LeeStephen Abini-AgbomsonKristjan GretarssonJonathan M BurgAllison R HickmanLu SunSaarang GopinathHailey TaylorMatthew J MeinersMarcus A CheekWilliam RiceEvgeny NudlerChao LuMichael-Christopher KeoghDiego PasiniKarim-Jean ArmachePublished in: bioRxiv : the preprint server for biology (2023)
We reveal the molecular mechanism of nucleosomal H2AK119Ub deubiquitination by human BAP1/ASXL1.