Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis.

Difan LuWenchao Mao

Published in: Clinical and investigative medicine. Medecine clinique et experimentale (2023)

HVT regimen did not reduce the mortality of patients with sepsis/septic shock and was not associated with a significant improvement in outcomes. The TSA result showed that more RCTs with high quality and large sample sizes are needed to further confirm the results.

Keyphrases

septic shock
clinical trial
study protocol
risk factors
cardiovascular events
phase iii
coronary artery disease
metabolic syndrome
randomized controlled trial
intensive care unit
open label