Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors.

Yingjie ZhuXin PeiArdijana NovajJeremy SettonDaniel BronderFatemeh DerakhshanPier SelenicaNiamh McDermottMehmet OrmanSarina PlumShyamal SubramanyanSara H BravermanBiko McMillanSonali SinhaJennifer MaAndrea GazzoAtif KhanSamuel BakhoumSimon N PowellJorge S Reis-FilhoYingjie Zhu

Published in: Genome medicine (2024)

This study provides a means to solve the tumor suppressor paradox by identifying synthetic viability interactions and causal driver genes affected by large-scale CNAs in human cancers.

Keyphrases

copy number
mitochondrial dna
genome wide
endothelial cells
dna methylation
breast cancer risk
gene expression
induced pluripotent stem cells
pluripotent stem cells
genome wide identification