Systemic inflammatory response syndrome after transcatheter or surgical aortic valve replacement.
Brian R LindmanJacob S GoldsteinMichael E NassifAlan ZajariasEric NovakAnjan TibrewalaAnna M VatterottCassandra LawlerRalph J DamianoMarc R MoonJennifer S LawtonJohn M LasalaHersh S ManiarPublished in: Heart (British Cardiac Society) (2015)
Severe SIRS was associated with a higher mortality after SAVR or TAVR. It occurred more commonly after SAVR and had a greater effect on mortality in diabetic patients. These findings may have implications for treatment decisions in patients with AS, may help explain differences in outcomes between different AVR approaches and identify diabetic patients as a high-risk subgroup to target in clinical trials with therapies to attenuate SIRS.
Keyphrases
- aortic valve replacement
- aortic stenosis
- aortic valve
- inflammatory response
- clinical trial
- transcatheter aortic valve implantation
- transcatheter aortic valve replacement
- ejection fraction
- left ventricular
- cardiovascular events
- lipopolysaccharide induced
- phase iii
- early onset
- risk factors
- cardiovascular disease
- randomized controlled trial
- drug induced
- lps induced
- adipose tissue
- insulin resistance
- atrial fibrillation
- replacement therapy
- phase ii
- study protocol