Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study.
Rachel C Nolan-KenneyMengling LiuOmar AkhandPeter A CalabresiFriedemann PaulAxel PetzoldLisanne BalkAlexander Ulrich BrandtElena H Martínez-LapiscinaShiv SaidhaPablo VillosladaAbdullah Abu Al-HassanRaed BehbehaniElliot M FrohmanTeresa FrohmanJoachim HavlaBernhard HemmerHong JiangBenjamin KnierThomas KornLetizia LeocaniAthina PapadopoulouMarco PisaHanna ZimmermannSteven L GalettaLaura J Balcernull nullPublished in: Annals of neurology (2019)
Intereye differences of 5μm for retinal nerve fiber layer and 4μm for macular ganglion cell + inner plexiform layer are robust thresholds for identifying unilateral optic nerve lesions. These thresholds may be useful in establishing the presence of asymptomatic and symptomatic optic nerve lesions in multiple sclerosis and could be useful in a new version of the diagnostic criteria. Our findings lend further validation for utilizing the visual system in a multiple sclerosis clinical trial setting. Ann Neurol 2019;85:618-629.