The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions.
Laura SecomandiMichela BorghesanMichael C VelardeMarco DemariaPublished in: Human reproduction update (2022)
In most countries of the Organization for Economic Co-operation and Development, the average age at which women give birth is above 30 years. Currently, in countries such as the Netherlands, Australia, Spain, Finland, Germany and the UK, birth rates among 30- to 34-year-olds are now higher than in any other age groups. This review will provide new knowledge and scientific advancement on the senescence mechanisms during female reproductive aging, and benefit fundamental and clinical scientists and professionals in the areas of reproduction, cancer, immunobiology and fibrosis.
Keyphrases
- dna damage
- pregnancy outcomes
- endothelial cells
- gestational age
- papillary thyroid
- healthcare
- polycystic ovary syndrome
- stress induced
- physical activity
- squamous cell
- cross sectional
- pregnant women
- squamous cell carcinoma
- human health
- risk assessment
- insulin resistance
- childhood cancer
- skeletal muscle
- cervical cancer screening
- preterm birth