Parkin mRNA Expression Levels in Peripheral Blood Mononuclear Cells in Parkin-Related Parkinson's Disease.
Nikolaos PapagiannakisHui LiuChristos KorosAthina-Maria SimitsiMaria StamelouMatina ManiatiElena Buena-AtienzaChrysoula KartanouGeorgia KaradimaPeriklis MakrythanasisGiannis VatsellasEnza Maria ValenteThomas GasserLeonidas StefanisPublished in: Movement disorders : official journal of the Movement Disorder Society (2024)
Assessment of PRKN mRNA levels in PBMCs may be a useful way to screen for biallelic pathogenic variants in the PRKN gene. Suspicion for certain variants in a heterozygous state may also be raised based on low PRKN mRNA levels. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.