Characterization of inflammation and insulin resistance in high-fat diet-induced male C57BL/6J mouse model of obesity.

Dimiter B AvtanskiValentin A PavlovKevin J TraceyLeonid Poretsky

Published in: Animal models and experimental medicine (2019)

Male C57BL/6J mice on 9 weeks HFD providing 60 kcal energy from fat display impaired insulin sensitivity and chronic inflammation, thus making this DIO mouse model appropriate for studies of early stages of obesity-related pathology.

Keyphrases

high fat diet induced
mouse model
insulin resistance
oxidative stress
high fat diet
adipose tissue
metabolic syndrome
skeletal muscle
type diabetes
fatty acid
body mass index
preterm birth