Increased Interferon Signaling in Vaginal Tissue of Patients With Primary Sjögren Syndrome.
Annie VisserJolien F van NimwegenRick WilbrinkSilvia C LiefersKarin van der TuukMarian J E MouritsGilles F H DiercksJoost BartBert Van der VegtLéon C L T van KempenHendrika BootsmaFrans G M KroeseGwenny M VerstappenPublished in: The Journal of rheumatology (2024)
Upregulation of IFN signaling in vaginal tissue of women with pSS, along with its association with tissue pathology, suggests that IFNs contribute to inflammation of the vaginal wall and potentially also to clinical symptomatology (ie, vaginal dryness).