Differences in inflammatory pathways between Dutch South Asians versus Dutch Europids with type 2 diabetes.
Maaike E StraatBorja Martinez-TellezHuub J van EykMaurice B BizinoSuzanne van VeenEleonora VianelloRinke StienstraTom H M OttenhoffHildo J LambJohannes W A SmitIngrid M JazetPatrick C N RensenMariëtte R BoonPublished in: The Journal of clinical endocrinology and metabolism (2022)
South Asian patients with T2D show a more activated IFN signaling pathway compared to Europid patients with T2D, which is more pronounced in females than males. We speculate that a more activated IFN signaling pathway may contribute to the more rapid progression of T2D in South Asians compared with Europids.