Proteomic aging clock (PAC) predicts age-related outcomes in middle-aged and older adults.

Due to its associations and predictive value for all-cause mortality and multiple incident diseases, PAC has the potential to serve as a valuable tool for assessing the effects of geoscience-guided interventions. It facilitates the evaluation of risk for multiple conditions in a disease-free population; thereby, contributing to the prevention of initial diseases, which vary among individuals and may subsequently lead to additional comorbidities.