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Surrogate threshold effect based on a meta-analysis for the predictive value of progression-free survival for overall survival in hormone receptor-positive, HER2-negative metastatic breast cancer.

Michael Patrick LuxSarah BöhmeStephanie HücherigUlli JeratschNiclas KürschnerDiana Lüftner
Published in: Breast cancer research and treatment (2019)
Based on the derived STE, it is possible to draw conclusions on a significant effect in OS for a hypothetical trial demonstrating an upper confidence limit of HRPFS < 0.60 in PFS. However, only final OS results are able to confirm if a clinical relevant difference in survival time can be achieved.
Keyphrases
  • free survival
  • metastatic breast cancer
  • clinical trial
  • randomized controlled trial