PDZ-binding kinase inhibitor OTS514 suppresses the proliferation of oral squamous carcinoma cells.
Mikako KatoAkinobu OtaTakayuki OnoSivasundaram KarnanToshinori HyodoRahman Md LutfurMuhammad Nazmul HasanMaho OndaSayuri KondoKunihiro ItoAkifumi FuruhashiTomio HayashiHiroyuki KonishiShinobu TsuzukiYoshitaka HosokawaYoshiaki KazaokaPublished in: Oral diseases (2023)
OTS514 suppressed the proliferation of OSCC cells by downregulating the expression of E2F target genes and induced apoptosis by mediating the p53 signaling pathway. These results highlight the clinical application of PBK inhibitors in the development of molecular-targeted therapeutics against OSCC.
Keyphrases
- induced apoptosis
- signaling pathway
- pi k akt
- epithelial mesenchymal transition
- poor prognosis
- high grade
- binding protein
- endoplasmic reticulum stress
- genome wide
- small molecule
- oxidative stress
- cell cycle arrest
- low grade
- gene expression
- dna binding
- single molecule
- genome wide identification
- transcription factor
- bioinformatics analysis