Age-Related RPE changes in Wildtype C57BL/6J Mice between 2 and 32 Months.

Debresha A SheltonIsabelle GefkeVivian SummersYong-Kyu KimHanyi YuYana GetzSalma FerdousKevin DonaldsonKristie LiaoJack T PapaniaMicah A ChrenekJeffrey H BoatrightJohn M Nickerson

Published in: bioRxiv : the preprint server for biology (2024)

The marked increase of cytoplasmic alpha-catenin expression and subretinal immune cell deposition, and decreased visual output coincide with regional changes in RPE cell morphometrics when stratified by age. These cumulative changes in the RPE morphology showed predictive regional patterns of stress associated with loss of RPE integrity.

Keyphrases

poor prognosis
single cell
epithelial mesenchymal transition
stem cells
binding protein
skeletal muscle
heat stress