In vitro differentiation of cGMP-grade retinal pigmented epithelium from human embryonic stem cells.

Fernando H LojudiceRodrigo Antonio Brant FernandesFrancesco InnocentiCarlos E FrancioziPriscila CristovamMaurício MaiaMari C SogayarRubens Belfort Junior

Published in: International journal of retina and vitreous (2019)

These results showed that functional RPE cells can be produced efficiently and suggested the possibility of scaling-up to aim at therapeutic protocols for retinal diseases associated with RPE degeneration.

Keyphrases

embryonic stem cells
optical coherence tomography
diabetic retinopathy
induced apoptosis
endothelial cells
cell cycle arrest
optic nerve
nitric oxide
induced pluripotent stem cells
pluripotent stem cells
endoplasmic reticulum stress
cell death
oxidative stress
protein kinase
cell proliferation