Endothelial UCP2 Is a Mechanosensitive Suppressor of Atherosclerosis.

Jiang-Yun LuoChak Kwong ChengLei HeYujie PuYang ZhangXiao LinAimin XuChi Wai LauXiao Yu TianRonald Ching Wan MaHanjoong Jo Yu Huang

Published in: Circulation research (2022)

Altogether, our studies uncover that UCP2 is novel mechanosensitive gene under the control of fluid shear stress and KLF2 in ECs. UCP2 expression is critical for endothelial proinflammatory response and atherogenesis. Therapeutic strategies enhancing UCP2 level may have therapeutic potential against atherosclerosis.

Keyphrases

cardiovascular disease
endothelial cells
poor prognosis
genome wide
transcription factor
gene expression
copy number
long non coding rna