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miR-200 family members reduce senescence and restore idiopathic pulmonary fibrosis type II alveolar epithelial cell transdifferentiation.

Silvia MoimasFrancesco SaltonBeata KosmiderNadja RingMaria Concetta VolpeKarim BahmedLuca BragaMichael RehmanSimone VodretMaria Laura GrazianiMarla R WolfsonNathaniel MarchettiThomas J RogersMauro GiaccaGerard J CrinerSerena ZacchignaMarco Confalonieri
Published in: ERJ open research (2019)
We demonstrated that ATII cells from IPF patients express senescence and EMT markers, and display a reduced ability to transdifferentiate into ATI cells. Transfection with certain miR-200 family members rescues this phenotype, reducing senescence and restoring transdifferentiation marker expression.
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