miR-200 family members reduce senescence and restore idiopathic pulmonary fibrosis type II alveolar epithelial cell transdifferentiation.
Silvia MoimasFrancesco SaltonBeata KosmiderNadja RingMaria Concetta VolpeKarim BahmedLuca BragaMichael RehmanSimone VodretMaria Laura GrazianiMarla R WolfsonNathaniel MarchettiThomas J RogersMauro GiaccaGerard J CrinerSerena ZacchignaMarco ConfalonieriPublished in: ERJ open research (2019)
We demonstrated that ATII cells from IPF patients express senescence and EMT markers, and display a reduced ability to transdifferentiate into ATI cells. Transfection with certain miR-200 family members rescues this phenotype, reducing senescence and restoring transdifferentiation marker expression.
Keyphrases
- idiopathic pulmonary fibrosis
- cell proliferation
- long non coding rna
- dna damage
- end stage renal disease
- endothelial cells
- poor prognosis
- chronic kidney disease
- long noncoding rna
- ejection fraction
- interstitial lung disease
- stress induced
- newly diagnosed
- induced apoptosis
- peritoneal dialysis
- prognostic factors
- oxidative stress
- patient reported outcomes
- signaling pathway
- binding protein