Psychosis-Like Behavior and Hyperdopaminergic Dysregulation in Human α-Synuclein BAC Transgenic Rats.

Alexia PolissidisMaria KoronaiouVasia KolliaEffrosyni KoronaiouModestos Nakos-BimposMarios BogiongkoSofia VrettouKaterina KaraliNicolas CasadeiOlaf RiessSergio P SardiMaria XilouriLeonidas Stefanis

Published in: Movement disorders : official journal of the Movement Disorder Society (2020)

Our findings demonstrate a potential role of α-synuclein in Parkinson's disease psychosis and provide evidence of region-specific perturbations prior to neurodegeneration phenoconversion. The reported phenotype coincides with the latest clinical findings that suggest a premotor hyperdopaminergic state may occur, while at the same time, premotor psychotic symptoms are increasingly being recognized. © 2020 International Parkinson and Movement Disorder Society.

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