Efficacy and safety of live varicella zoster vaccine in diabetes: a randomized, double-blind, placebo-controlled trial.

Atsuko HataF InoueY HamamotoM YamasakiJ FujikawaH KawaharaY KawasakiS HonjoH KoshiyamaE MoriishiY MoriT Ohkubo

Published in: Diabetic medicine : a journal of the British Diabetic Association (2015)

Our previous results demonstrated that varicella zoster vaccine safely enhanced VZV-specific immunity in elderly people with or without diabetes. The results of this study showed that varicella zoster vaccine can be used safely, but it cannot boost virus-specific immunity in elderly people with diabetes when administered with concurrent PPSV23. Alternative strategies are needed to prevent VZV-associated diseases in this population.

Keyphrases

type diabetes
cardiovascular disease
double blind
glycemic control
middle aged
clinical trial
study protocol
placebo controlled
community dwelling
squamous cell carcinoma
randomized controlled trial
metabolic syndrome
skeletal muscle
insulin resistance
phase iii