Unveiling the therapeutic potential of thymol from Nigella sativa L. seed: selective anticancer action against human breast cancer cells (MCF-7) through down-regulation of Cyclin D1 and proliferative cell nuclear antigen (PCNA) expressions.
V VahithaGrowther LaliSaradh PrasadPonmurugan KaruppiahGopalu KarunakaranMohamad S AlSalhiPublished in: Molecular biology reports (2024)
Thymol, extracted from NS, demonstrated specific cytotoxic effects on MCF-7 cells by suppressing the expression of Cyclin D1 and PCNA, suggesting its potential as an effective drug for MCF-7. However, additional in vivo research is required to ascertain its efficacy and safety in medical applications.
Keyphrases
- breast cancer cells
- cell cycle arrest
- cell cycle
- induced apoptosis
- cell death
- endothelial cells
- poor prognosis
- pi k akt
- healthcare
- single cell
- cell therapy
- induced pluripotent stem cells
- oxidative stress
- emergency department
- cell proliferation
- signaling pathway
- dengue virus
- binding protein
- long non coding rna
- zika virus
- adverse drug
- anti inflammatory