A Network Pharmacology-Based Approach to Investigating the Mechanisms of Fushen Granule Effects on Intestinal Barrier Injury in Chronic Renal Failure.

Miaoru HanHangxing YuKang YangPanying LiuHaifeng YanZhihua YangHongtao Yang

Published in: Evidence-based complementary and alternative medicine : eCAM (2021)

FSG had a protective effect on urinary toxin-induced intestinal epithelial barrier injury in chronic renal failure, and its mechanism may be related to the upregulation of Nrf2/HO-1 signal transduction and the inhibition of tissue oxidative stress and inflammatory responses. Screening CRF targets and identifying the corresponding FSG components by network pharmacological methods is a practical strategy to explain the mechanism of FSG in improving gastrointestinal dysfunction in CRF.

Keyphrases

oxidative stress
diabetic rats
drug induced
escherichia coli
dna damage
ischemia reperfusion injury
cell proliferation
poor prognosis
high glucose
signaling pathway
network analysis
endothelial cells
long non coding rna
heat shock
stress induced