Expression of IL-34 correlates with macrophage infiltration and prognosis of diffuse large B-cell lymphoma.

Osamu NoyoriYoshihiro KomoharaHesham NasserMasateru HiyoshiChaoya MaCheng PanJoaquim CarrerasNaoya NakamuraAi SatoKiyoshi AndoYutaka OkunoKisato NosakaMasao MatsuokaShinya Suzu

Published in: Clinical & translational immunology (2019)

Our results raise the possibility that IL-34 in lymphoma tissues of DLBCL patients recruits monocytes, leading to the higher number of macrophages in the tissues and poor prognosis of patients. IL-34 may be an additional therapeutic target of DLBCL.

Keyphrases

diffuse large b cell lymphoma
poor prognosis
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
epstein barr virus
gene expression
peritoneal dialysis
prognostic factors
adipose tissue