Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa.
Telma de SousaMichel HébraudMaria de Lurdes Nunes Enes DapkeviciusLuís MaltezJosé Eduardo PereiraRosa CapitaCarlos Alonso-CallejaGilberto IgrejasPatrícia PoetaPublished in: International journal of molecular sciences (2021)
In recent years, the effectiveness of antimicrobials in the treatment of Pseudomonas aeruginosa infections has gradually decreased. This pathogen can be observed in several clinical cases, such as pneumonia, urinary tract infections, sepsis, in immunocompromised hosts, such as neutropenic cancer, burns, and AIDS patients. Furthermore, Pseudomonas aeruginosa causes diseases in both livestock and pets. The highly flexible and versatile genome of P. aeruginosa allows it to have a high rate of pathogenicity. The numerous secreted virulence factors, resulting from its numerous secretion systems, the multi-resistance to different classes of antibiotics, and the ability to produce biofilms are pathogenicity factors that cause numerous problems in the fight against P. aeruginosa infections and that must be better understood for an effective treatment. Infections by P. aeruginosa represent, therefore, a major health problem and, as resistance genes can be disseminated between the microbiotas associated with humans, animals, and the environment, this issue needs be addressed on the basis of an One Health approach. This review intends to bring together and describe in detail the molecular and metabolic pathways in P. aeruginosa's pathogenesis, to contribute for the development of a more targeted therapy against this pathogen.
Keyphrases
- pseudomonas aeruginosa
- biofilm formation
- candida albicans
- cystic fibrosis
- public health
- mental health
- healthcare
- urinary tract infection
- end stage renal disease
- staphylococcus aureus
- acinetobacter baumannii
- systematic review
- randomized controlled trial
- escherichia coli
- chronic kidney disease
- genome wide
- newly diagnosed
- ejection fraction
- intensive care unit
- squamous cell carcinoma
- young adults
- papillary thyroid
- peritoneal dialysis
- transcription factor
- human health
- gene expression
- risk assessment
- combination therapy
- antimicrobial resistance
- copy number
- extracorporeal membrane oxygenation
- respiratory failure