Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy.
Yao-Chung LiuJunsu KwonEmiliano FabianiZhijian XiaoYanjing V LiuMatilde Y FolloJinqin LiuHuijun HuangChong GaoJun LiuGiulia FalconiLia ValentiniCarmelo GurnariCarlo FinelliLucio CoccoJin-Hwang LiuAdrianna I JonesJunyu YangHenry YangJulie A I ThomsAshwin UnnikrishnanJohn E PimandaRongqing PanMahmoud A BassalMaria T VosoDaniel Geoffrey TenenLi ChaiPublished in: The New England journal of medicine (2022)
By combining analysis of patient samples with CRISPR-DiR technology, we found that demethylation and up-regulation of an oncogene after treatment with a hypomethylating agent can indeed occur and should be further studied. (Funded by Associazione Italiana per la Ricerca sul Cancro and others.).