Bioimaging of alloantigen-stimulated regulatory T cells in rat vascularized composite allotransplantation.

Hui-Yun ChengSheri K L TayChih-Jen WenChih-Fan LinAline Yen-Ling WangLing-Yi ShihShiao-Chin LiuEiji KobayashiCheng-Hung LinFu-Chan Wei

Published in: PloS one (2018)

Sorted Tregs induced donor-specific tolerance to VCA in rats. Live cell tracking demonstrated that activated CD4+CD25+FoxP3+ Tregs targeted primarily to the lymph nodes and VCA. The Tregs migrated to the secondary grafted donor skin and contributed to the maintenance of donor-specific tolerance. These behaviors were associated with phenotypic changes induced by donor antigen stimulation. Increased expression of CCR4 and CCL22 in VCA skin may also be relevant.

Keyphrases

regulatory t cells
dendritic cells
lymph node
poor prognosis
soft tissue
oxidative stress
diabetic rats
wound healing
immune response
high glucose
drug delivery
long non coding rna
drug induced
rectal cancer
locally advanced
neoadjuvant chemotherapy