XMU-MP-1 induces growth arrest in a model human mini-organ and antagonises cell cycle-dependent paclitaxel cytotoxicity.

Ellen MitchellCharlotte E L MellorTalveen S Purba

Published in: Cell division (2020)

XMU-MP-1 perturbs epithelial cell cycle progression in a model human mini-organ. This may arise as an off-target effect, especially when XMU-MP-1 has been described to strongly inhibit 21 additional kinases beyond MST1/2. Therefore, whilst these effects may be dependent on tissue context, researchers should exercise caution when interpreting the effects of XMU-MP-1, especially in tissues with actively proliferating cell populations.

Keyphrases

cell cycle
cell proliferation
endothelial cells
induced pluripotent stem cells
gene expression
pluripotent stem cells
stem cells
high intensity