The development and characterization of a long acting anti-thrombotic von Willebrand factor (VWF) aptamer.

Shuhao ZhuJames C GilbertPaul HatalaWarren HarveyZicai LiangShan GaoDaiwu KangBernd Jilma

Published in: Journal of thrombosis and haemostasis : JTH (2020)

BT200 has shown promising inhibition of human VWF in vitro and prevented arterial occlusion in non-human primates. These data including a long half-life after subcutaneous injections provide a strong rationale for ongoing clinical development of BT200.

Keyphrases

endothelial cells
pluripotent stem cells
gold nanoparticles
electronic health record
big data
machine learning
sensitive detection
deep learning
quantum dots