Dynamic causal modeling in PTSD and its dissociative subtype: Bottom-up versus top-down processing within fear and emotion regulation circuitry.

Andrew A NicholsonKarl J FristonPeter ZeidmanSherain HarricharanMargaret C McKinnonMaria DensmoreRichard W J NeufeldJean ThébergeFrank CorriganRakesh JetlyDavid SpiegelRuth A Lanius

Published in: Human brain mapping (2017)

These results suggest the contrasting symptom profiles of PTSD and its dissociative subtype (hyper- vs. hypo-emotionality, respectively) may be driven by complementary changes in directed connectivity corresponding to bottom-up defensive fear processing versus enhanced top-down regulation. Hum Brain Mapp 38:5551-5561, 2017. © 2017 Wiley Periodicals, Inc.

Keyphrases

resting state
white matter
posttraumatic stress disorder
functional connectivity
social support
prefrontal cortex
depressive symptoms
patient reported
cerebral ischemia
brain injury