Permeation Challenges of Drugs for Treatment of Neurological Tuberculosis and HIV and the Application of Magneto-Electric Nanoparticle Drug Delivery Systems.
Sinaye MhambiDavid FisherMoise B Tchoula TchokonteAdmire DubePublished in: Pharmaceutics (2021)
The anatomical structure of the brain at the blood-brain barrier (BBB) creates a limitation for the movement of drugs into the central nervous system (CNS). Drug delivery facilitated by magneto-electric nanoparticles (MENs) is a relatively new non-invasive approach for the delivery of drugs into the CNS. These nanoparticles (NPs) can create localized transient changes in the permeability of the cells of the BBB by inducing electroporation. MENs can be applied to deliver antiretrovirals and antibiotics towards the treatment of human immunodeficiency virus (HIV) and tuberculosis (TB) infections in the CNS. This review focuses on the drug permeation challenges and reviews the application of MENs for drug delivery for these diseases. We conclude that MENs are promising systems for effective CNS drug delivery and treatment for these diseases, however, further pre-clinical and clinical studies are required to achieve translation of this approach to the clinic.
Keyphrases
- human immunodeficiency virus
- drug delivery
- blood brain barrier
- antiretroviral therapy
- hepatitis c virus
- hiv aids
- hiv infected
- mycobacterium tuberculosis
- hiv positive
- induced apoptosis
- randomized controlled trial
- cerebral ischemia
- signaling pathway
- combination therapy
- endothelial cells
- multiple sclerosis
- drug release
- cell death
- endoplasmic reticulum stress
- resting state