Passenger Gene Coamplifications Create Collateral Therapeutic Vulnerabilities in Cancer.
Yi BeiLuca BraméMarieluise KirchnerRaphaela Fritsche-GuentherSéverine KunzAnimesh BhattacharyaMara-Camelia RusuDennis GurgenFrank P B DubiosJulia K C KoppkeJutta ProbaNadine WittstruckOlga Alexandra SidorovaRocio Chamorro GonzálezHeathcliff Dorado GarciaLotte BruecknerRobin XuMadalina GiurgiuElias Rodriguez-FosQinghao YuBastiaan SpanjaardRichard P KocheClemens A SchmittJohannes Hubertus SchulteAngelika EggertKerstin HaaseJennifer A KirwanAnja I H HagemannPhilipp MertinsJan R DorrAnton G HenssenPublished in: Cancer discovery (2024)
We demonstrate that coamplification of passenger genes, which were largely neglected in cancer biology in the past, can create distinct cancer dependencies. Because passenger coamplifications are frequent in cancer, this principle has the potential to expand target discovery in oncology. This article is featured in Selected Articles from This Issue, p. 384.