Evidence of a Positive Link between Consumption and Supplementation of Ascorbic Acid and Bone Mineral Density.
Mariangela RondanelliGabriella PeroniFederica FossariViviana VecchioMilena Anna FalivaMaurizio NasoTariq A AlalwanEnrica Di PaoloAntonella RivaGiovanna PetrangoliniMara NichettiAlice TartaraPublished in: Nutrients (2021)
In animal models it has been shown that ascorbic acid (AA) is an essential cofactor for the hydroxylation of proline in collagen synthesis. However, there are still no precise indications regarding the role of AA in maintaining bone health in humans, so the aim of this narrative review was to consider state of the art on correlation between bone mineral density (BMD), AA dietary intake and AA blood levels, and on the effectiveness of AA supplement in humans. This review included 25 eligible studies. Fifteen studies evaluated correlations between AA intake and BMD: eight studies demonstrated a positive correlation between AA dietary intake and BMD in 9664 menopausal women and one significant interaction between effects of AA intake and hormone therapy. These data were also confirmed starting from adolescence (14,566 subjects). Considering studies on AA blood concentration and BMD, there are four (337 patients) that confirm a positive correlation. Regarding studies on supplementation, there were six (2671 subjects), of which one was carried out with AA supplementation exclusively in 994 postmenopausal women with a daily average dose of 745 mg (average period: 12.4 years). BMD values were found to be approximately 3% higher in women who took supplements.
Keyphrases
- bone mineral density
- postmenopausal women
- body composition
- case control
- healthcare
- public health
- systematic review
- randomized controlled trial
- newly diagnosed
- physical activity
- polycystic ovary syndrome
- ejection fraction
- climate change
- machine learning
- mesenchymal stem cells
- pregnant women
- body mass index
- insulin resistance
- artificial intelligence
- type diabetes